Clean and Green Approach for N-formylation of Amines using Formic acid under neat reaction condition

In recent years much effort has been carried out on formylations of amines. N-formyl compounds have been widely used in organic synthesis as protecting group of amines [1]. They are also used for synthesis of pharmaceutically important heterocylces [2-5]. Formamides are the Lewis bases, which are known to catalyze reactions such as allylations [6] and hydrosilylations [7] of carbonyl compounds. In additions to this they have been useful amino-protecting groups in peptide synthesis [8].